Calculate $2$ to the power of $10$ and get $1024$.
$$\frac{\mathrm{d}}{\mathrm{d}y}(1024+3^{12}y)$$
Calculate $3$ to the power of $12$ and get $531441$.
$$\frac{\mathrm{d}}{\mathrm{d}y}(1024+531441y)$$
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is $0$. The derivative of $ax^{n}$ is $nax^{n-1}$.