Identify all the factors and their highest power in all expressions. Multiply the highest powers of these factors to get the least common multiple.
$$\int F_{216}O\mathrm{d}O$$
Factor out the constant using $\int af\left(O\right)\mathrm{d}O=a\int f\left(O\right)\mathrm{d}O$.
$$F_{216}\int O\mathrm{d}O$$
Since $\int O^{k}\mathrm{d}O=\frac{O^{k+1}}{k+1}$ for $k\neq -1$, replace $\int O\mathrm{d}O$ with $\frac{O^{2}}{2}$.
$$F_{216}\times \frac{O^{2}}{2}$$
Simplify.
$$\frac{F_{216}O^{2}}{2}$$
If $F\left(O\right)$ is an antiderivative of $f\left(O\right)$, then the set of all antiderivatives of $f\left(O\right)$ is given by $F\left(O\right)+C$. Therefore, add the constant of integration $C\in \mathrm{R}$ to the result.