$$(4p^{4}q)(-4pq^{4})(-4pqr^{3})$$
$64r^{3}\left(pq\right)^{6}$
$$4p^{5}q\left(-4\right)q^{4}\left(-4\right)pqr^{3}$$
$$4p^{6}q\left(-4\right)q^{4}\left(-4\right)qr^{3}$$
$$4p^{6}q^{5}\left(-4\right)\left(-4\right)qr^{3}$$
$$4p^{6}q^{6}\left(-4\right)\left(-4\right)r^{3}$$
$$-16p^{6}q^{6}\left(-4\right)r^{3}$$
$$64p^{6}q^{6}r^{3}$$
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$192r^{2}\left(pq\right)^{6}$
